More than 8,500 individuals from the field of pharmaceutical research are expected to attend this year’s AAPS Annual Meeting and Exposition November 8 - 12, 2009 at the Los Angeles Convention Center in California. During the meeting, scientists from around the world will have the opportunity to present new research, methods and technologies as they relate to the field of pharmaceutical sciences.
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The Stowers Institute’s Gerton Lab has provided new evidence to clarify the structure of nucleosomes containing Cse4, a centromere-specific histone protein required for proper kinetochore function, which plays a critical role in the process of mitosis. The work, conducted in yeast cells, was published in the most recent issue of Molecular Cell. The centromeric nucleosome acts as a guide for the position of the kinetochore.
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Using an RNA-powered nanomotor, University of Cincinnati (UC) biomedical engineering researchers have successfully developed an artificial pore able to transmit nanoscale material through a membrane. In a study led by UC biomedical engineering professor Peixuan Guo, PhD, members of the UC team inserted the modified core of a nanomotor, a microscopic biological machine, into a lipid membrane.
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A new study resolves a 130-year-old mystery over the developmental origin of specialized skin cells involved in touch sensation. The findings will appear in the October 5, 2009 issue of the Journal of Cell Biology (online September 28). First described in 1875, Merkel cells are neuroendocrine cells that reside in the vertebrate epidermis, passing mechanical stimuli on to sensory neurons.
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The popular oral contraceptives Yaz and Yasmin have been tainted recently by safety concerns raised by researchers, health advocates and lawyers for plaintiffs who have filed lawsuits against manufacturer Bayer Healthcare, the New York Times reports. These groups argue that the drugs put women at higher risk for strokes, blood clots and other health problems than some other oral contraceptives.
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GlaxoSmithKline (GSK) Chief Executive Andrew Witty on Friday announced Brazil has agreed to buy roughly $2.2 billion of the company’s vaccine for pneumococcal disease, Synflorix, for a period of at least eight years, in exchange for a technology transfer, eventually allowing Brazil to manufacture the vaccine itself, the Wall Street Journal reports.
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JHP Pharmaceuticals, LLC (”JHP”) announced that it had developed, and received approval by the FDA for Dantrium® IV (dantrolene sodium for injection), a rapidly mixing product. Dantrium® IV now reconstitutes in approximately 20 seconds, which is 4 times faster than before, saving valuable time and effort during a malignant hyperthermia (MH) emergency.
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More than 8,500 individuals from the field of pharmaceutical research are expected to attend this year’s AAPS Annual Meeting and Exposition November 8 - 12, 2009 at the Los Angeles Convention Center in California. During the meeting, scientists from around the world will have the opportunity to present new research, methods and technologies as they relate to the field of pharmaceutical sciences.
Lees meer..

BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) announced that it is initiating a Phase 2 study of BCX4208 for the treatment of gout. The primary objective of BioCryst’s Phase 2 study is to determine the effect of different doses of orally administered BCX4208 on serum uric acid levels in patients with gout. The gout trial is expected to enroll up to 120 subjects. “Over the last few decades gout has markedly increased in incidence and prevalence, both in the U.S. and elsewhere.
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Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) announced that it has begun enrolling patients in a Phase 1 study of ONX 0801, a novel alpha-folate receptor-mediated thymidylate synthase (TS) inhibitor, as a potential treatment for advanced solid tumors. This open-label, dose-finding study will evaluate the safety and pharmacokinetics of ONX 0801 in patients with advanced solid tumors.
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